forkhead box protein K2; interleukin enhancer-binding factor 1; cellular transcription factor ILF-1 (FOXK1, FOXK2 ILF ILF1)

Function

• recognizes the core sequence 5'-TAAACA-3'
• binds to NFAT-like motifs (purine-rich) in IL2 promoter
• also binds to HIV-1 long terminal repeat
• may be involved in both positive & negative regulation of viral & cellular promoter elements
• phosphorylated upon DNA damage, probably by ATM or ATR

Cofactor: binds 1 Mg+2 per subunit

Structure

• C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity
• contains 1 FHA domain
• contains 1 fork-head DNA-binding domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=3

Expression

• expressed in both lymphoid & non-lymphoid cells

More general terms

• interleukin enhancer binding factor
• phosphoprotein
• forkhead family transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q01167.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3607
• OMIM: https://mirror.omim.org/entry/147685
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3607