nuclear factor 1 A-type; NF1-A; nuclear factor 1/A; CCAAT-box-binding transcription factor; CTF; nuclear factor I/A; NF-I/A; NFI-A; TGGCA-binding protein (NFIA, KIAA1439)

Function

• recognizes & binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral & cellular promoters & in the origin of replication of adenovirus type 2
• these proteins are individually capable of activating transcription & replication
• binds DNA as a homodimer
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the CTF/NF-I family
• contains 1 CTF/NF-I DNA-binding domain

Compartment

nucleus

More general terms

• nuclear factor 1
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4774
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4774
• OMIM: https://mirror.omim.org/entry/600727
• UniProt: http://www.uniprot.org/uniprot/Q12857.html