ATF-like basic leucine zipper transcriptional factor B-ATF (SF-HT-activated gene 2, SFA-2, BATF)

Function

• negative regulator of AP-1 mediated transcription by binding to Jun proteins
• Jun/B-ATF heterodimers bind DNA preferentially at the AP1-site (TRE) (consensus: 5'-TGA[CG]TCA-3') & weaker at the cAMP responsive region (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') but are transcriptionally inert
• forms heterodimers with JUN, JUNB & JUND
• interacts with IFI35
• phosphorylated

Structure

• belongs to the bZIP family
• contains 1 bZIP domain

Compartment

nucleus

Expression

• expressed at highest levels in lung, & at lower levels in placenta, liver, kidney, spleen, & peripheral blood
• strongly expressed in mature B- & T-lymphocytes

Pathology

• detected in SW480 colorectal cancer cell line & in several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma

More general terms

• basic leucine zipper (bZIP) family protein
• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q16520.html