Max-interacting transcriptional repressor MAD3 (Max-associated protein 3, MAX dimerization protein 3, Myx, MXD3, MAD3)

Function

• transcriptional repressor
• binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'
• antagonizes MYC transcriptional activity by competing for MAX
• suppresses MYC dependent cell transformation
• efficient DNA binding requires dimerization with another bHLH protein
• binds DNA as a heterodimer with MAX
• interacts with SIN3A & SIN3B

Structure

contains 1 basic helix-loop-helix domain (bHLH)

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• transcriptional silencer (transcriptional repressor)
• basic helix loop helix (bHLH) family transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BW11.html