Krueppel-like factor 10; EGR-alpha; transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1 (KLF10, TIEG, TIEG1)

Function

• transcriptional repressor involved in the regulation of cell growth
• inhibits cell growth
• binds to the consensus sequence 5'-GGTGTG-3'
• ubiquitinated; mediated by SIAH1 & leading to its subsequent proteasomal degradation (probable)

Structure

• belongs to the Sp1 C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus

Expression

induced by TGFB1

More general terms

• Krueppel-like factor
• transcriptional silencer (transcriptional repressor)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7071
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7071
• OMIM: https://mirror.omim.org/entry/601878
• UniProt: http://www.uniprot.org/uniprot/Q13118.html