Max dimerization protein 4; Max dimerizer 4; class C basic helix-loop-helix protein 12; bHLHc12; Max-associated protein 4; Max-interacting transcriptional repressor MAD4 (MXD4, BHLHC12, MAD4)

Function

• transcriptional repressor
• binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'
• antagonizes MYC transcriptional activity by competing for MAX & suppresses MYC dependent cell transformation (putative)
• efficient DNA binding requires dimerization with another bHLH protein
• binds DNA as a heterodimer with MAX
• interacts with SIN3A AND SIN3B
• interacts with RNF17 (putative)

Structure

• contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus (putative)

More general terms

• transcriptional silencer (transcriptional repressor)

Additional terms

• MAX-associated protein; MAX dimerizing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10608
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10608
• UniProt: http://www.uniprot.org/uniprot/Q14582.html