zinc finger protein 354C; kidney, ischemia, & developmentally-regulated protein 3; hKID3 (ZNF354C, KID3)

Function

• role as transcription repressor (putative)
• suppresses osteogenic effects of RUNX2
• binds to 5'-CCACA-3' core sequence
• role in osteoblastic differentiation (putative)
• interacts with RUNX2
• binds consensus element OSE2

Structure

• belongs to the krueppel C2H2-type zinc-finger protein family
• contains 11 C2H2-type zinc fingers involved in nuclear targeting & DNA-binding
• contains 1 KRAB domain, not required for nuclear targeting or for DNA binding

Compartment

nucleus

Expression

• expressed in kidney & skeletal muscle
• very low expression in brain & heart
• during development, expressed in brain with very low expression in lung & liver

More general terms

• zinc finger protein
• transcriptional silencer (transcriptional repressor)
• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86Y25.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30832