syntaxin binding protein 5 (tomosyn-1, lethal[2] giant larvae protein homolog 3, STXBP5, LLGL3)

Function

• Ca+2-dependent exocytosis
• neurotransmitter release
• inhibits membrane fusion between transport vesicles & plasma membrane
• modulates assembly of trans-SNARE complexes between transport vesicles & plasma membrane
• inhibits translocation of GLUT4 from intracellular vesicles to plasma membrane
• competes with STXBP1 for STX1 binding
• interacts with STX1A, STX1B
• component of STX1/STXBP5/SNAP25/SYT1/STXBP5 complex
• component o STXBP5/STX4A/SNAP23STXBP5 complex

Compartment

• cytoplasm, peripheral membrane protein, vesicular membranes, plasma membrane, synapses, synaptic vesicles

More general terms

• UNC-18 homolog or syntaxin binding protein

Database

• OMIM: https://mirror.omim.org/entry/604586
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=134957
• UniProt: http://www.uniprot.org/uniprot/Q5T5C0.html