PCR/in-situ hybridization for acute lymphoblastic leukemia

Genetics

• associated genetic aberrations:
  • chromosomal translocation t9q34:22q11 (Philadelphia chromosome) 10-15% (ALL-L1, ALL-L2)
  • chromosomal translocation t8q24.1:14q32 (ALL-L3)

Indications

• acute lymphoblastic leukemia (ALL)

Specimen

• bone marrow
• whole blood (ACD or EDTA)
• store body fluid at 4 degrees C
• store tissue at -20 degrees C or below

More general terms

• molecular diagnostic test

Additional terms

• acute lymphoblastic leukemia (ALL)
• chromosomal translocation t9q34.1:22q11 (Philadelphia chromosome; bcr/abl)