epithelial Ca+2 channel 2; transient receptor potential cation channel subfamily V member 6; TrpV6; CaT-like; CaT-L; Ca+2 transport protein 1; CaT1; ECaC2 (TRPV6, ECAC2)

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Function

Ca+2 selective cation channel
probably involved in Ca+2 uptake in various tissues, including Ca+2 reabsorption in intestine
the channel is activated by low internal Ca+2 level, probably including intracellular Ca+2 store depletion
the Ca+2 current exhibits an inward rectification
inactivation includes both, a rapid Ca+2-dependent & a slower Ca+2-calmodulin-dependent mechanism
- the slower mechanism may be regulated by phosphorylation
in vitro, is slowly inhibited by Mg+2 (voltage-independent)
heteromeric assembly with TRPV5 seems to modify channel properties
TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (putative)
phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation
homotetramer & probably heterotetramer with TRPV5
interacts with TRPV5
interacts with S100A10 & probably with the ANAX2-S100A10 heterotetramer
interaction with S100A10 is required for the trafficking to the plasma membrane
interacts with BSPRY (putative)
interacts with calmodulin

glycosylated (putative)
belongs to the transient receptor (TC 1.A.4) family TrpV subfamily, TRPV6 sub-subfamily contains 5 ANK repeats

expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum & colon, & in pancreas, placenta, prostate & salivary gland. expressed at moderate levels in liver, kidney & testis

expressed in locally advanced prostate cancer, metastatic & androgen-insensitive prostatic lesions but not detected in healthy prostate tissue & benign prostatic hyperplasia