epithelial Ca+2 channel 1; transient receptor potential cation channel subfamily V member 5; TrpV5; Ca+2 transport protein 2; CaT2; ECaC; ECaC1; Osm-9-like TRP channel 3; OTRPC3 (TRPV5, ECAC1)

Function

• constitutively active Ca+2 selective cation channel
• thought to be involved in Ca+2 reabsorption in kidney & intestine
• the channel is activated by low internal Ca+2 level & the current exhibits an inward rectification
• a Ca+2-dependent feedback regulation includes fast channel inactivation & slow current decay
• heteromeric assembly with TRPV6 seems to modify channel properties
• TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (putative)
• activated by WNK3
• homotetramer & probably heterotetramer with TRPV6
• interacts with TRPV6
• interacts with S100A10 & probably with the ANAX2-S100A10 heterotetramer
• interaction with S100A10 is required for the trafficking to the plasma membrane
• interacts with calmodulin
• interacts with BSPRY, which results in its inactivation (putative)

Structure

• glycosylated
• belongs to the transient receptor (TC 1.A.4) family TrpV subfamily, TRPV5 sub-subfamily
• contains 5 ANK repeats

Compartment

• apical cell membrane; multi-pass membrane protein
• colocalized with S100A10 & ANAX2 along the apical domain of kidney distal tubular cells (putative)
• glycosylated form in the cell membrane is increased by the presence of WNK3

Expression

• expressed at high levels in kidney, small intestine & pancreas
• expressed at lower levels in testis, prostate, placenta, brain, colon & rectum

More general terms

• transient receptor potential cation channel subfamily V (TRPV)
• ankyrin repeat domain protein (ANKRD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56302
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56302
• OMIM: https://mirror.omim.org/entry/606679
• UniProt: http://www.uniprot.org/uniprot/Q9NQA5.html