C-C motif chemokine 21; 6Ckine; beta-chemokine exodus-2; secondary lymphoid-tissue chemokine; SLC; small-inducible cytokine A21 (CCL21, SCYA21, UNQ784/PRO1600)

Function

• inhibits hemopoiesis & stimulates chemotaxis
• chemotactic in vitro for thymocytes & activated T-cells
• not chemotactic for B-cells, macrophages, or neutrophils
• preferential activity towards naive T-cells
• may play a role in mediating homing of lymphocytes to secondary lymphoid organs
• binds to CCR7

Structure

• monomer
• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Expression

• expressed in high endothelial venules of lymph nodes, spleen & appendix > small intestine, thyroid gland & trachea > thymus, bone marrow, liver, & pancreas
• also found in tonsil, fetal heart & fetal spleen

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6366
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6366
• OMIM: https://mirror.omim.org/entry/602737
• UniProt: http://www.uniprot.org/uniprot/O00585.html