C-C motif chemokine 14; chemokine CC-1/CC-3; HCC-1/HCC-3; HCC-1(1-74); NCC-2; small-inducible cytokine A14 (CCL14, NCC2, SCYA14)

Function

• weak activities on human monocytes
• acts via receptors that also recognize MIP-1 alpha
• induces intracellular Ca+2 changes & enzyme release
• not chemotactic at concentrations of 100-1000 nM,
• inactive on T-cells, neutrophils, & eosinophils
• enhances proliferation of CD34 myeloid progenitor cells
• the processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, & T-cells & is a ligand for CCR1, CCR3 & CCR5
• the N-terminal processed forms HCC-1(3-74), HCC-1(4-74) & HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion into plasma

Structure

• HCC-1(1-74) is partially O-glycosylated
  • the O-linked glycan consists of one gal-galNAc disaccharide, further modified by two N-acetylneuraminic acids
• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Alternative splicing

named isoforms=2; HCC-1, HCC-3

Expression

• expressed constitutively in several normal tissues: spleen, liver, skeletal & heart muscle, gut, & bone marrow
• present at high concentrations (1-80 nM) in plasma

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6358
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6358
• OMIM: https://mirror.omim.org/entry/601392
• UniProt: http://www.uniprot.org/uniprot/Q16627.html