C-X-C motif chemokine 14; chemokine BRAK; MIP-2G; small-inducible cytokine B14 (CXCL14, MIP2G, NJAC, SCYB14, PSEC0212, UNQ240/PRO273)

Function

• potent chemoattractant for neutrophils
• weaker chemoattractant for dendritic cells
• not chemotactic for T-cells, B-cells, monocytes, NK cells
• does not inhibit proliferation of myeloid progenitors in colony formation assays
• ubiquitinated, followed by degradation by the proteasome

Structure

• the destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway
• belongs to the intercrine alpha (chemokine CxC) family

Compartment

secreted

Expression

• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas
• highly expressed in normal tissue without inflammatory stimuli
• infrequently expressed in cancer cell lines
• weakly expressed in myeloid dendritic cells
• not detected in lung or unstimulated peripheral blood lymphocytes
• up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS)

Notes

• uncertain whether Met-1 or Met-13 is the initiator

More general terms

• CXC chemokine; alpha chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9547
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9547
• OMIM: https://mirror.omim.org/entry/604186
• UniProt: http://www.uniprot.org/uniprot/O95715.html