HIV envelope glycoprotein gp120
Jump to navigation
Jump to search
Introduction
Derived from HIV envelope glycoprotein gp160
Function
- attaches virus to host lymphoid cell by binding to CD4
- interaction induces a structural rearrangement creating high-affinity binding site for a chemokine coreceptor, i.e. CXCR4 &/or CCR5
- interaction allows gp120 to maintain a cryptic conformation, protected from neutralizing antibodies
- ligand for CD209 (found on dendritic cells) & CLEC4M (found on endothelial cells of liver sinusoids & lymph node sinuses)
- allows capture of viral particles at mucosal surfaces by these cells & subsequent transmission to permissive cells
More general terms
References
Database
- UniProt: http://www.uniprot.org/uniprot/P03378.html
- UniProt: http://www.uniprot.org/uniprot/P03375.html
- UniProt: http://www.uniprot.org/uniprot/P04582.html
- UniProt: http://www.uniprot.org/uniprot/P12488.html
- UniProt: http://www.uniprot.org/uniprot/P03377.html
- UniProt: http://www.uniprot.org/uniprot/P05879.html
- UniProt: http://www.uniprot.org/uniprot/P04581.html
- UniProt: http://www.uniprot.org/uniprot/P04578.html
- UniProt: http://www.uniprot.org/uniprot/P04624.html
- UniProt: http://www.uniprot.org/uniprot/P12489.html
- UniProt: http://www.uniprot.org/uniprot/P20871.html
- UniProt: http://www.uniprot.org/uniprot/P31819.html
- UniProt: http://www.uniprot.org/uniprot/P04583.html
- UniProt: http://www.uniprot.org/uniprot/P19551.html
- UniProt: http://www.uniprot.org/uniprot/P05877.html
- UniProt: http://www.uniprot.org/uniprot/P12490.html
- UniProt: http://www.uniprot.org/uniprot/P18799.html
- UniProt: http://www.uniprot.org/uniprot/P20888.html
- UniProt: http://www.uniprot.org/uniprot/P04579.html
- UniProt: http://www.uniprot.org/uniprot/P19550.html
- UniProt: http://www.uniprot.org/uniprot/P19549.html
- UniProt: http://www.uniprot.org/uniprot/P05878.html
- UniProt: http://www.uniprot.org/uniprot/P31872.html
- UniProt: http://www.uniprot.org/uniprot/P05880.html
- UniProt: http://www.uniprot.org/uniprot/P35961.html
- UniProt: http://www.uniprot.org/uniprot/P12487.html
- UniProt: http://www.uniprot.org/uniprot/P12491.html
- UniProt: http://www.uniprot.org/uniprot/P04580.html
- UniProt: http://www.uniprot.org/uniprot/P05882.html
- UniProt: http://www.uniprot.org/uniprot/P05881.html
- UniProt: http://www.uniprot.org/uniprot/P18094.html
- UniProt: http://www.uniprot.org/uniprot/P24105.html
- UniProt: http://www.uniprot.org/uniprot/P17755.html
- UniProt: http://www.uniprot.org/uniprot/P15831.html
- UniProt: http://www.uniprot.org/uniprot/P18040.html
- UniProt: http://www.uniprot.org/uniprot/P05883.html
- UniProt: http://www.uniprot.org/uniprot/P04577.html
- UniProt: http://www.uniprot.org/uniprot/P32536.html
- UniProt: http://www.uniprot.org/uniprot/P12449.html
- UniProt: http://www.uniprot.org/uniprot/P20872.html