polyomavirus middle T antigen (PVMT)
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Introduction
PVMT binds to c-src protein Tyr-527 & prevents phosphorylation. It activates c-src protein & itself becomes phosphorylated on Tyr-315 & Tyr-250. PVMT also binds to grb2 & shc & perhaps Sos, PI-3-kinase & 14-3-3 (4).
More general terms
References
- ↑ Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
- ↑ Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell. 1991 Jan 25;64(2):281-302. Review. Erratum in: Cell 1991 May 31;65(5):following 914. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1846320
- ↑ Dilworth SM, Brewster CE, Jones MD, Lanfrancone L, Pelicci G, Pelicci PG. Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc. Nature. 1994 Jan 6;367(6458):87-90. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7509037
- ↑ Aitken A. 14-3-3 proteins on the MAP. Trends Biochem Sci. 1995 Mar;20(3):95-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7709434