adenosylhomocysteinase 2; AdoHcyase 2; DC-expressed AHCY-like molecule; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1, DCAL, XPVKONA)

Function

• amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1
• interacts with ITPR1
• competes with IP3 for interaction with ITPR1 & attenuates IP3-induced Ca+2 release through the ITPR1 from the endoplasmic reticulum

Cofactor: binds 1 NAD per subunit

Structure

• the PEST region is essential for interaction with ITPR1
• the PDZ-binding region is required for maximal interaction with ITPR1 & is also responsible for the IP3-insensitive
• interaction with ITPR1 (putative)
• belongs to the adenosylhomocysteinase family

Compartment

endoplasmic reticulum (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in dendritic cells
• expression increases markedly during activation of blood & skin dendritic cells (Langerhans cells)
• expression is diminished in terminally differentiated tonsil dendritic cells

More general terms

• hydrolase

Additional terms

• inositol triphosphate [IP3] receptor P400 (ITPR, IP3-R)
• inositol-1,4,5-triphosphate (IP3)
• S-adenosyl homocysteine hydrolase (ADOHCYASE, adenosylhomocysteinase, AHCY, SAHH)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10768
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10768
• OMIM: https://mirror.omim.org/entry/607826
• UniProt: http://www.uniprot.org/uniprot/O43865.html