fermitin family homolog 3; kindlin-3; MIG2-like protein; Unc-112-related protein 2 (FERMT3, KIND3, MIG2B, URP2)

Function

• plays a central role in cell adhesion in hematopoietic cells
• acts by activating integrin beta-1-3 (ITGB1, ITGB2 & ITGB3)
• required for integrin-mediated platelet adhesion & leukocyte adhesion to endothelial cells
• required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (putative)
• isoform 2 may act as a repressor of NF-kappa-B & apoptosis
• interacts with ITGB1, ITGB2 & ITGB3 (via cytoplasmic tails) (putative)

Structure

• the FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain
• belongs to the kindlin family
• contains 1 FERM domain
• contains 1 PH domain

Compartment

• cell projection, podosome (putative)
• present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells (putative)

Alternative splicing

named isoforms=2

Expression

• highly expressed in lymph node
• expressed in thymus, spleen & leukocytes
• weakly expressed in placenta, small intestine, stomach, testis & lung

Pathology

• defects in FERMT3 are the cause of leukocyte adhesion deficiency-3
• overexpressed in B-cell malignancies

More general terms

• kindlin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83706
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83706
• OMIM: https://mirror.omim.org/entry/607901
• OMIM: https://mirror.omim.org/entry/612840
• UniProt: http://www.uniprot.org/uniprot/Q86UX7.html