plakophilin-4; p0071 (PKP4)

Function

• may play a role in junctional plaques
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with PDZD2 (putative)
• interacts (via the C-terminus) with FRMPD2 (via the 2nd PDZ domain)

Structure

• belongs to the beta-catenin family
• contains 9 ARM repeats

Compartment

• cell junction, desmosome
• colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells

Alternative splicing

named isoforms=2; long, short

More general terms

• plakophilin
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604276
• UniProt: http://www.uniprot.org/uniprot/Q99569.html