SHC-transforming protein 3; neuronal Shc; N-Shc; protein Rai; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3; SH2 domain protein C3 (SHC3, NSHC, SHCC)

Function

• signaling adapter that couples activated growth factor receptors to signaling pathway in neurons
• involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons
• Tyr-phosphorylated
• interacts with the Trk receptors (phospho-Tyr-dependent)
• once activated, binds to GRB2
• interacts with activated EGF receptors

Structure

• contains 1 PID domain
• contains 1 SH2 domain

Alternative splicing

named isoforms=2

Expression

• mainly expressed in brain
  • highly expressed in the cerebral cortex, frontal lobe, temporal lobes, occipital pole, hippocampus, caudate nucleus & amygdala
  • expressed at low level in the cerebellum, medulla & spinal cord
• also expressed in pancreas
• hardly detectable in other tissues

More general terms

• Shc proto-oncogene protein (Shc transforming protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53358
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53358
• OMIM: https://mirror.omim.org/entry/605263
• UniProt: http://www.uniprot.org/uniprot/Q92529.html