phospholipid scramblase 1; PL scramblase 1; Ca+2-dependent phospholipid scramblase 1; erythrocyte phospholipid scramblase; MmTRA1b (PLSCR1)

Function

• may facilitate ATP-independent bidirectional transbilayer migration of phospholipids upon binding Ca+2, resulting in a loss of phospholipid asymmetry in the plasma membrane
• role in the initiation of fibrin clot formation (putative)
• role in activation of mast cells
• role in recognition of apoptotic & injured cells by the reticuloendothelial system
• role in the antiviral response of interferon (IFN) by amplifying & enhancing the IFN response through increased expression of select subset of antiviral genes
• may contribute to cytokine-regulated cell proliferation & differentiation
• interacts with ABL

Cofactor: Ca+2

Structure

• palmitoylated
• belongs to the phospholipid scramblase family

Compartment

• membrane; single-pass type 2 membrane protein

Expression

• expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney & pancreas
• not expressed in brain & skeletal muscle
• induced by phosphorylation by PKC
• induced by IFNB1/IFN-beta in response to a viral infection

More general terms

• phospholipid scramblase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5359
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5359
• OMIM: https://mirror.omim.org/entry/604170
• UniProt: http://www.uniprot.org/uniprot/O15162.html