interleukin-1 receptor accessory protein-like 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; oligophrenin-4; three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL1, OPHN4)
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Function
- may regulate secretion & presynaptic differentiation via inhibition of the N-type voltage-gated Ca+2 channel
- may activate the MAP kinase JNK
- role in presynaptic & postsynaptic differentiation & dendritic spine formation in neurons
- homodimer
- interacts (Ca+2-independent) with NCS1
- interacts (via extracellular region) with PTPRD
- this interaction is required for IL1RAPL1-mediated synapse formation
Structure
- belongs to the interleukin-1 receptor family
- contains 3 Ig-like C2-type domains
- contains 1 TIR domain
Compartment
- cell membrane; single-pass type 1 membrane protein
- cytoplasm
- cell projection, axon (putative)
- cell projection, dendrite (putative)
- may localize to the cell body & growth cones of dendrite-like processes
Alternative splicing
named isoforms=1
Expression
- expressed at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra, thalamus > tonsil, prostate, testis, small intestine, placenta, colon, fetal liver
Pathology
- defects in IL1RAPL1 are a cause of nonspecific X-linked mental retardation