corticotropin-releasing factor receptor 1; CRF-R; CRF1; corticotropin-releasing hormone receptor 1; CRH-R 1 (CRHR1 CRFR CRFR1 CRHR)

Function

• receptor for corticotropin releasing factor
• high-affinity CRF binding
• activity of this receptor is mediated by G proteins which activate adenylyl cyclase
• C-terminal Ser or Thr may be phosphorylated

Structure

belongs to the G-protein coupled receptor 2 family

Compartment

cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=4 CRF-R1-R4, CRF-R2: major isoform CRF-R3: does not bind to CRF with high affinity

Expression

• predominantly expressed in the cerebellum, pituitary, cerebral cortex & olfactory lobe

More general terms

• corticotropin-releasing factor/hormone [CRF/CRH] receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1394
• OMIM: https://mirror.omim.org/entry/122561
• UniProt: http://www.uniprot.org/uniprot/P34998.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1394