pituitary adenylate cyclase-activating polypeptide type 1 receptor; PACAP type I receptor; PACAP-R-1 (ADCYAP1R1)

Function

• receptor for PACAP-27 & PACAP-38.
• activity is mediated by G proteins which activate adenylyl cyclase
• may regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, & other catecholamines
• may play a role in spermatogenesis & sperm motility
• causes smooth muscle relaxation & secretion in the gastrointestinal tract

Structure

belongs to the G-protein coupled receptor 2 family

Compartment

cell membrane; multi-pass membrane protein

Expression

• most abundant in the brain
• low expression in the lung, liver, thymus, spleen, pancreas & placenta

More general terms

• pituitary adenyl cyclase activating polypeptide [PACAP] receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:117
• OMIM: https://mirror.omim.org/entry/102981
• UniProt: http://www.uniprot.org/uniprot/P41586.html