Ly-6/neurotoxin-like protein 1;endogenous prototoxin LYNX1; testicular tissue protein Li 112 (LYNX1)

Function

• modulates nicotinic acetylcholine receptors (putative)
• binds directly to nAChRs
  • interacts with nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) & alpha-7 (CHRNA7) subunits
  • interacts with CHRNA4 probably in endoplasmic reticulum prior to nAChR pentameric assembly (putative)
• prevents plasticity in the primary visual cortex late in life (putative)

Structure

• contains 1 UPAR/Ly6 domain

Compartment

• cell membrane, GPI-anchor
• cell projection, dendrite, endoplasmic reticulum
• detected in Purkinje cells soma & proximal dendrites

Alternative splicing

named isoforms=2

Notes

• based on a naturally occurring readthrough transcript which produces a LYNX1-SLURP2 fusion protein
• isoform 1 is considered to be an endogenous prototoxin, that shares a N-terminal three-finger structure with snake alpha-neurotoxins
• UniProt :accession Q9BZG9 withdrawn 2017

More general terms

• glypiated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=66004
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:66004
• OMIM: https://mirror.omim.org/entry/606110
• UniProt: http://www.uniprot.org/uniprot/P0DP58.html