transducin-like enhancer protein 2; enhancer of split groucho-like protein 2; ESG2 (TLE2)

Function

• transcriptional corepressor that binds to a number of transcription factors
• inhibits transcriptional activation mediated by CTNNB1 & TCF family members in Wnt signaling
• effects of full-length TLE family members may be modulated by association with dominant-negative AES (putative)
• homooligomer & heterooligomer with other family members
• binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 & HES5

Structure

• belongs to the WD repeat groucho/TLE family
• contains 6 WD repeats

Compartment

nucleus

Expression

• expressed in all tissues examined, including heart, brain, & muscle

More general terms

• transducin-like enhancer protein (ESG)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7089
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7089
• OMIM: https://mirror.omim.org/entry/601041
• UniProt: http://www.uniprot.org/uniprot/Q04725.html