palmitoyltransferase ZDHHC17 (zinc finger DHHC domain-containing protein 17, DHHC-17, huntingtin-interacting protein 14, huntingtin-interacting protein 3, huntingtin-interacting protein HYPH, NF-kappa-B-activating protein 205, MAPK-activating protein PM11, ZDHHC17, HIP14, HIP3, KIAA0946, HSPC294)

Function

• palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 & HD
• role in sorting or targeting of critical proteins involved in the initiating events of endocytosis at plasma membrane ?
• role in NF-kappa-B signaling pathway ?
• binds HD, interaction inversely correlated to length of polyglutamine tract in huntingtin protein
• autopalmitoylated

palmitoyl-CoA + protein-cysteine <--> S-palmitoyl protein + CoA

Structure

• belongs to the DHHC palmitoyltransferase family.
• contains 1 DHHC-type zinc finger
  • contains 5 ANK repeats

Compartment

Golgi membrane, cytoplasmic vesicle membrane

Alternative splicing

named isoforms=3

Expression

• expressed in all brain regions, cortex, cerebellum, occipital lobe, caudate > spinal cord
• expressed in testis, pancreas, heart, kidney

Pathology

• has transforming activity

More general terms

• acyltransferase
• zinc finger protein
• transmembrane 6 protein

Additional terms

• Huntington's disease [HD] protein (huntingtin) or IT15 protein

Database

• OMIM: https://mirror.omim.org/entry/607799
• UniProt: http://www.uniprot.org/uniprot/Q8IUH5.html