protein vav-3 (VAV3)

Function

• exchange factor for GTP-binding proteins RhoA, RhoG &, to a lesser extent, Rac1
• binds to GTPases without bound nucleotide
• interacts with the PH domain of APS

Structure

• contains 1 CH domain (calponin-homology domain)
• contains 1 DH domain (DBL-homology domain)
• contains 1 PH domain
• contains 1 phorbol-ester/DAG-type zinc finger
• contains 1 SH2 domain
• contains 2 SH3 domains

Alternative splicing

named isoforms=2

More general terms

• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/605541
• UniProt: http://www.uniprot.org/uniprot/Q9UKW4.html