zinc finger HIT domain-containing protein 1; cyclin-G1-binding protein 1; zinc finger protein subfamily 4A member 1; p18 Hamlet (ZNHIT1, CGBP1, ZNFN4A1)

Function

• seems to play a role in p53-mediated apoptosis
• phosphorylated on Thr by MAPK11 or MAPK14
• stress-induced ZNHIT1 is mainly regulated at the protein level
• interacts with MAPK11 & MAPK14
• component of the chromatin-remodeling SRCAP complex

Structure

• belongs to the ZNHIT1 family
• contains 1 HIT-type Zn+2 finger

Expression

induced by DNA damage

More general terms

• zinc finger protein
• phosphoprotein

Component of

• chromatin-remodeling SRCAP complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10467
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10467
• UniProt: http://www.uniprot.org/uniprot/O43257.html