kidney glutaminase (platelet glutaminase, phosphate activated glutaminase, GLS, GLS1, KIAA0838)

Function

• catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine

L-glutamine + H2O <--> L-glutamate + NH3

Structure

• belongs to the glutaminase family
• contains 1 ANK repeat

Compartment

mitochondria (probable)

Alternative splicing

named isoforms=3

Expression

• KGA isoform:
  • predominantly brain & kidney, not liver
• GAC isoform:
  • cardiac muscle, pancreas, not liver or brain
• GAM isoform:
  • cardiac & skeletal muscle

Genetics

Gene locus: 2q32-q34

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• glutaminase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2744
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2744
• OMIM: https://mirror.omim.org/entry/138280
• UniProt: http://www.uniprot.org/uniprot/O94925.html