EP300-interacting inhibitor of differentiation 2 (EID-2, EID-1-like inhibitor of differentiation 2, CREBBP/EP300 inhibitor 2, EID2, CRI2)

Function

• interacts with EP300
• acts as a repressor of MYOD- dependent transcription & muscle differentiation
• inhibits EP300 histone acetyltransferase activity
• acts as a repressor of TGFB/SMAD transcriptional responses
• may act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex
• heterodimer with EID2B
• interacts with the C-terminus of EP300
• interacts with HDAC1 & HDAC2
• interacts with SMAD2, SMAD4 & with the MH2 domain of SMAD3

Structure

• N-terminal portion of EID2 is required for nuclear localization

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• most abundantly expressed in placenta
• highly expressed in liver, brain, heart, skeletal muscle, & kidney

More general terms

• EP300-interacting inhibitor of differentiation

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1631
• UniProt: http://www.uniprot.org/uniprot/Q8N6I1.html