mastermind homolog MAML3 (MAML3, KIAA1816)

Function

• transcriptional coactivator for NOTCH proteins
• amplifies NOTCH-induced transcription of HES1
• interacts through its N-terminal region with ankyrin repeat region of Notch proteins NOTCH1, NOTCH2, NOTCH3 & NOTCH4
• forms a DNA-binding complex with Notch proteins & RBPSUH/RBP-J kappa

Structure

• belongs to the mastermind family
• C-terminal domain is required for transcriptional activation

Compartment

• nucleus, nuclear speckle

More general terms

• mastermind-like family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55534
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55534
• OMIM: https://mirror.omim.org/entry/608991
• UniProt: http://www.uniprot.org/uniprot/Q96JK9.html