chromobox protein homolog 7 (CBX7)

Function

• role in maintaining the transcriptionally repressive state of genes
• modifies chromatin, rendering it heritably changed in its expressibility (putative)
• regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity
• component of a chromatin-associated polycomb complex (PcG) (putative)
• interacts with RING1, but not with BMI1, EED or EZH2

Structure

contains 1 chromo domain

Compartment

nucleus

More general terms

• chromobox protein homolog

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23492
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23492
• OMIM: https://mirror.omim.org/entry/608457
• UniProt: http://www.uniprot.org/uniprot/O95931.html