RB1-inducible coiled-coil protein 1 (RB1CC1, KIAA0203, RBICC)

Function

• role in regulation of RB1 expression
• DNA-binding transcription factor
• regulates RB1 pathway
• role in muscular differentiation
• tumor suppressor

Compartment

nucleus

Expression

• correlates with expression of RB1
• expression with maturation of osteocytes, chondrocytes, & skeletal muscle cells

Pathology

• expressed in cultured osteosarcoma cells.
• 20% of primary breast cancers may contain mutations in RB1CC1

More general terms

• DNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/606837
• UniProt: http://www.uniprot.org/uniprot/Q8TDY2.html