transcription factor RFX3; regulatory factor X 3 (RFX3)

Function

• transcription factor required for ciliogenesis & islet cell differentiation during endocrine pancreas development
• essential for the differentiation of nodal monocilia & left-right asymmetry specification during embryogenesis
• required for biogenesis of motile cilia by governing growth & beating efficiency of motile cells
• also required for ciliated ependymal cell differentiation
• regulates the expression of genes involved in
  • ciliary assembly (DYNC2LI1, FOXJ1 & BBS4)
  • ciliary motility (DNAH11, DNAH9 & DNAH5) (putative)
• together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP cells (polypeptide-producing)
• regulates transcription by forming a heterodimer with another RFX protein & binding to the X-box in the promoter of target genes
• acts as a transcription factor
• represses transcription of MAP1A in non-neuronal cells but not in neuronal cells

Structure

• belongs to the RFX family
• contains 1 H-T-H motif winged-type DNA-binding domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=3

More general terms

• DNA-binding protein
• transcription factor (TF)

Additional terms

• regulatory factor X (RFX)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5991
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5991
• OMIM: https://mirror.omim.org/entry/601337
• UniProt: http://www.uniprot.org/uniprot/P48380.html