zinc finger protein 260 (ZNF260, ZFP260)

Function

• transcription factor
• cardiac regulator
• effector of alpha1-adrenergic signaling
• binds to PE response elements (PERE) present in promoter of genes such as ANF/NPPA (binds DNA); direct transcriptional activator of NPPA
• interacts with GATA4, a key cardiac regulator
• up-regulated by activation of alpha1-adrenergic receptors

Structure

• belongs to the krueppel C2H2-type zinc-finger protein family.
• contains 13 C2H2-type zinc fingers

Compartment

nucleus

More general terms

• C2H2 type zinc finger protein
• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q3ZCT1.html