A disintegrin & metalloproteinase with thrombospondin type 1 motif 1; ADAMTS-1; ADAM-TS 1; ADAM-TS1; METH-1 (ADAMTS1, KIAA1346, METH1)

Function

• cleaves aggrecan, a cartilage proteoglycan, & may play role in its turnover (putative)
• cleaves aggrecan at the 1938-Glu-|-Leu-1939 site, within the chondroitin sulfate attachment domain
• has angiogenic inhibitor activity
• active metalloprotease
• may be associated with various inflammatory processes
• may play role in follicular rupture
• precursor is cleaved by a furin endopeptidase

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• spacer domain & TSP type-1 domains are important for a tight interaction with the extracellular matrix
• conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
• contains 1 disintegrin domain
• contains 1 peptidase M12B domain
• contains 3 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Pathology

• may play role in development of cancer cachexia

More general terms

• ADAMTS protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9510
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9510
• OMIM: https://mirror.omim.org/entry/605174
• UniProt: http://www.uniprot.org/uniprot/Q9UHI8.html