collagen 8 alpha-2 (COL8A2, endothelial collagen)
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Function
- macromolecular component of the subendothelium
- major component of the Descemet's membrane (basement membrane) of corneal endothelium)
- also component of the endothelium of blood vessels
- necessary for migration & proliferation of vascular smooth muscle cells
- proteolytically cleaved by neutrophil elastase, in vitro
- Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains
- homotrimers, or heterotrimers in association with COL8A1
- four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers
Structure
contains 1 C1q domain
Compartment
Expression
- expressed primarily in subendothelium of large blood vessels
- also expressed in arterioles & venules in muscle, heart, kidney, spleen, umbilical cord, liver & lung
- also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea & sclera, & in the perichondrium of cartilage
- in the kidney, expressed in mesangial cells, glomerular endothelial cells, & tubular epithelial cells
- also expressed in mast cells, & in astrocytes during the repair process
- expressed in Descemet's membrane
Pathology
- possible role in atherogenesis via effect on proliferation of vascular smooth muscle cells
- up-regulated in diabetic nephropathy
- defects in COL8A2 are the cause of
More general terms
Component of
References
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1296
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1296
- OMIM: https://mirror.omim.org/entry/120252
- OMIM: https://mirror.omim.org/entry/136800
- OMIM: https://mirror.omim.org/entry/609140
- UniProt: http://www.uniprot.org/uniprot/P25067.html