complexin-2; complexin II; CPX II; synaphin-1 (CPLX2)

Function

• positively regulates a late step in synaptic vesicle exocytosis
• also involved in mast cell exocytosis (putative)
• binds to the SNARE core complex containing SNAP25, VAMP2 & STX1A (putative)

Structure

belongs to the complexin/synaphin family

Compartment

• cytoplasm, cytosol
• enriched at synaptic-releasing sites in mature neurons (putative)

Expression

• nervous system
• in hippocampus & cerebellum, expressed mainly by excitatory neurons

Pathology

• down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression
• down-regulated in cerebellum from patients with schizophrenia

More general terms

• complexin (synaphin)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10814
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10814
• OMIM: https://mirror.omim.org/entry/605033
• UniProt: http://www.uniprot.org/uniprot/Q6PUV4.html