protein SSXT; synovial sarcoma translocated to X chromosome protein; protein SYT (SS18, SSXT, SYT)

Function

• appears to function synergistically with RBM14 as a transcriptional coactivator
• isoform 1 & isoform 2 function in nuclear receptor coactivation
• isoform 1 & isoform 2 function in general transcriptional coactivation
• interacts with MLLT10

Structure

belongs to the SS18 family

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Expression

• fairly ubiquitously expressed
• expressed in synovial sarcomas & in other human cell lines
• fusion genes SSXT-SSX1 & SSXT-SSX2 are expressed only in synovial sarcomas

Pathology

• chromosomal translocation t(X;18)(p11.2;q11.2) involving SS18 may be a cause of synovial sarcoma
  • the translocation is specifically found in more than 80% of synovial sarcomas
  • the fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity
  • heterogeneity in the position of the breakpoint can occur (low frequency)

More general terms

• SSX family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6760
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6760
• OMIM: https://mirror.omim.org/entry/600192
• UniProt: http://www.uniprot.org/uniprot/Q15532.html