RNA-binding protein 14 (RNA-binding motif protein 14, RRM-containing coactivator activator/modulator, synaptotagmin-interacting protein, SYT-interacting protein, RBM14, SIP)

Function

• isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators, i.e. NCOA6 & CITED1
• isoform 2 functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6, CITED1
• isoform 1 interacts with NCOA6

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in all tissues tested, including: brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, peripheral blood lymphocytes

More general terms

• RNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96PK6.html