protein SSX1; synovial sarcoma, X breakpoint 1; cancer/testis antigen 5.1; CT5.1 (SSX1)
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Function
- could act as a modulator of transcription
Structure
Expression
- expressed at high level in the testis
- expressed at low level in thyroid
- not detected in tonsil, colon, lung, spleen, prostate, kidney, striated & smooth muscles
- detected in rhabdomyosarcoma & fibrosarcoma cell lines
- not detected in mesenchymal & epithelial cell lines
Pathology
- chromosomal translocation t(X;18)(p11.2;q11.2) involving SSX1 may be a cause of synovial sarcoma
- the translocation is specifically found in more than 80% of synovial sarcomas
- fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity
- heterogeneity in the position of the breakpoint can occur (low frequency)