chromosomal translocation t(X;18)(p11.2;q11.2) (synovial sarcoma)

Introduction

• chromosomal translocation t(X;18)(p11.2;q11.2) involving SS18 may be a cause of synovial sarcoma
  • the translocation is specifically found in more than 80% of synovial sarcomas
  • the fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity
  • heterogeneity in the position of the breakpoint can occur (low frequency)

More general terms

• chromosomal translocation