sterile alpha & TIR motif-containing protein 1; sterile alpha & armadillo repeat protein; sterile alpha motif domain-containing protein 2; SAM domain-containing protein 2; Tir-1 homolog (SARM1, KIAA0524, SAMD2, SARM)

Function

• innate immnune response (putative)
• does NOT act in Toll-like receptor signaling pathway
• acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- & TLR4-dependent genes
• specifically blocks TICAM1/TRIF-dependent transcription-factor activation & gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling
• negative regulator of NF-kappa-B & IRF activation
• interacts with & interferes with TICAM1/TRIF function

Structure

• contains 2 SAM (sterile alpha motif) domains
• contains 1 TIR domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

expressed in kidney, liver > placenta

More general terms

• sterile alpha motif domain-containing protein (SAMD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23098
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23098
• OMIM: https://mirror.omim.org/entry/607732
• UniProt: http://www.uniprot.org/uniprot/Q6SZW1.html