suppressor of cytokine signaling 5; SOCS-5; cytokine-inducible SH2 protein 6; CIS-6; cytokine-inducible SH2-containing protein 5 (SOCS5, CIS6, CISH5, CISH6, KIAA0671)

Function

• role in regulating T-helper cell differentiation by inhibition of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype
• can also partially inhibit IL6 & LIF signaling (putative)
• may be a substrate- recognition component of a SCF-like ECS (elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins (putative)
• protein modification; protein ubiquitination
• interacts, via the first 50 AA, with IL4RA (through a box 1-containing cytpolasmic domain) & inhibits IL4 signaling

Structure

• the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (putative)
• contains 1 SH2 domain
• contains 1 SOCS box domain

More general terms

• suppressor of cytokine signaling family (SOCS family protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9655
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9655
• OMIM: https://mirror.omim.org/entry/607094
• UniProt: http://www.uniprot.org/uniprot/O75159.html