serine/threonine protein kinase Nek3; HSPK 36; Never in mitosis A-related kinase 3; NimA-related protein kinase 3 (NEK3)

Function

• serine/threonine protein kinase
• influences neuronal morphogenesis & polarity through effects on microtubules
• regulates microtubule acetylation in neurons
• contributes to prolactin-mediated phosphorylation of PXN & VAV2
• implicated in prolactin-mediated cytoskeletal reorganization & motility of breast cancer cells through mechanisms involving RAC1 activation & phosphorylation of PXN & VAV2
• prolactin stimulates its activity
• phosphorylation at Thr-479 regulates its catalytic activity
• interacts with PXN, PRLR, VAV1 & VAV2 (prolactin-dependent)

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
• contains 1 protein kinase domain

Compartment

• cytoplasm (putative)
• cell projection, axon (putative)

Alternative splicing

named isoforms=2

Expression

• isoform 2 shows a high level of expression in testis, ovary & brain

Pathology

• up-regulated in breast cancer

More general terms

• serine/threonine protein kinase NEK

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4752
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4752
• OMIM: https://mirror.omim.org/entry/604044
• UniProt: http://www.uniprot.org/uniprot/P51956.html