P2Y purinoceptor 13; P2Y13; G-protein coupled receptor 86; G-protein coupled receptor 94 (P2RY13 GPR86 GPR94 FKSG77)

Function

• receptor for ADP
• coupled to Gi-proteins
• may play a role in hematopoiesis & the immune system

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• strong expression in spleen & adult brain
• lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, & adrenal
• not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta
• detected in lymph node & bone marrow
• weakly detected in peripheral blood mononuclear cells
• but not detected in polymorphonuclear leukocytes
• detected in all brain regions examined

Notes

• stimulation by ADP in stably transfected CHO cells results in inhibition of adenylyl cyclase & phosphorylation of MAP kinases MAPK3 & MAPK1 (pertussis toxin-sensitive)
• inhibition of adenylyl cyclase & phosphorylation of MAP kinases are signal transduction mechanisms that involve Gi proteins

More general terms

• G-protein coupled receptor; serpentine receptor

Database

• OMIM: https://mirror.omim.org/entry/606380
• UniProt: http://www.uniprot.org/uniprot/Q9BPV8.html