sphingosine 1-phosphate receptor 1; G-protein coupled receptor EDG1; S1P receptor 1; S1P1; sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; endothelial differentiation G-protein coupled receptor 1 (S1PR1, CHEDG1, EDG1)

Function

• receptor for the lysosphingolipid sphingosine 1-phosphate (S1P)
• inducible endothelial cell G-protein-coupled receptor
• may be involved in processes that regulate differentiation of endothelial cells
• seems to be coupled to Gi proteins
• S1P-induced endothelial cell migration requires the PKB/AKT1- mediated phosphorylation of Thr-236 within the 3rd intracellular loop of S1PR1

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed in endothelial cells > vascular smooth muscle cells, fibroblasts, melanocytes, & cells of epithelioid origin
• induced by the tumor promoter phorbol 12-myristate 13-acetate in the presence of cycloheximide

More general terms

• sphingosine 1-phosphate receptor; S1P receptor (S1PR)
• phosphoprotein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/601974
• UniProt: http://www.uniprot.org/uniprot/P21453.html