centaurin-alpha-2; Arf-GAP with dual PH domain-containing protein 2; Cnt-a2 (ADAP2, CENTA2)

Function

• GTPase-activating protein for the ADP ribosylation factor family (putative)
• binds phosphatidylinositol 3,4,5-trisphosphate (PtdinsP3) & inositol 1,3,4,5-tetrakisphosphate (insP4)
• possesses a stoichiometry of two binding sites for insP4 with identical affinity

Structure

• contains 1 Arf-GAP domain
• contains 2 PH domains

Compartment

• cytoplasm, cell membrane
• constitutively associated with the plasma membrane
• excluded from the nucleus

Alternative splicing

• named isoforms=2
• may be due to a competing acceptor splice site

Expression

• highly expressed in placenta, spleen, kidney, skeletal muscle & adrenal gland
• weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes
• not detected in spinal cord, brain, stomach, trachea, colon, lymph node & bone marrow

More general terms

• centaurin

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55803
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55803
• OMIM: https://mirror.omim.org/entry/608635
• UniProt: http://www.uniprot.org/uniprot/Q9NPF8.html