zinc fingers & homeoboxes protein 3; triple homeobox protein 1; zinc finger & homeodomain protein 3 (ZHX3, KIAA0395, TIX1)

Function

• acts as a transcriptional repressor
• regulator of podocyte gene expression during primary glomerular disease
• forms homodimers
• also forms heterodimers with ZHX1 & ZHX2
• heterodimerization with ZHX1 is a prerequisite for repressor activity
• interacts with NFYA

Structure

• belongs to the ZHX family
• contains 2 C2H2-type Zn+2 fingers
• contains 5 homeobox DNA-binding domains

Compartment

nucleus

Expression

• widely expressed
• high expression in kidney

More general terms

• homeobox protein
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23051
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23051
• OMIM: https://mirror.omim.org/entry/609598
• UniProt: http://www.uniprot.org/uniprot/Q9H4I2.html